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You start as an ingredient in the primordial soup, and try to create life. Solitaire, competitive, and cooperative play options. This is the first game in the Bios:Trilogy, being followed by Bios:Megafauna 2 and Bios:Origins 2. The Bios games are linked yet independent.
In Bios: Genesis, one to four players start as organic compounds shortly after Earth's formation, represented by up to three Biont tokens. The Amino Acids command Metabolism, the lipids create cells, the pigments control energy absorption and storage, and the nucleic acids control templated replication. Their goal is a double origin of life: first as Autocatalytic Life (a metabolic cycle reproducing, yet not replicating, its own constituents), and the second as Darwinian Life (an Organism using a template to replicate in an RNA world). Players can play cooperative, competitive, or solitaire.